Retina-Seal: Gene therapy mediated regulation of the blood retina barrier

Información del proyecto

Retina-Seal

Identificador del acuerdo de subvención: 101213062

DOI 10.3030/101213062

Fecha de la firma de la CE 11 Marzo 2025

Fecha de inicio 1 Mayo 2025

Fecha de finalización 31 Octubre 2026

Financiado con arreglo a

• European Research Council (ERC)

Coste total Sin datos

Aportación de la UE € 150 000,00

Coordinado por

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Objetivo

"Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 288 million by 2040, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition.
At the inner blood retina barrier (iBRB), claudin-5 is the most enriched component of the tight junctions of endothelial cells, regulating the paracellular diffusion of molecules into and out of the retina. As part of the on-going ERC Consolidator grant Retina-Rhythm, we now have a very large body of data suggesting “leaky” or “CLDN-5 depleted” retinal vasculature drives the accumulation of waste material known as drusen, the hallmark diagnostic feature of AMD. Therefore, methods aimed at enhancing CLDN-5 expression can potentially stabilize vascular integrity and prevent the onset of AMD (both dry and wet AMD). Here, we will develop novel adeno-associated viruses (AAV) that will directly regulate the expression of 2 novel target genes and effectively ""seal"" the blood retina barrier and stabilise disease progression."

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• ciencias médicas y de la salud › biotecnología médica › ingeniería genética › terapia génica
• ciencias naturales › ciencias biológicas › microbiología › virología
• ciencias médicas y de la salud › medicina clínica › oftalmología

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Programa(s)

• HORIZON.1.1 - European Research Council (ERC) Main Programme

Tema(s)

• ERC-2024-POC - ERC PROOF OF CONCEPT GRANTS

Convocatoria de propuestas

ERC-2024-POC

Régimen de financiación

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

Institución de acogida

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

• Aportación neta de la UEn: € 150 000,00
• Dirección: COLLEGE GREEN TRINITY COLLEGE ; D02 CX56 Dublin ; Irlanda
• Región: Ireland › Eastern and Midland › Dublin
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos

Beneficiarios (1)

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Irlanda

• Aportación neta de la UEn: € 150 000,00
• Dirección: COLLEGE GREEN TRINITY COLLEGE ; D02 CX56 Dublin
• Región: Ireland › Eastern and Midland › Dublin
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos