Objective
"Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 288 million by 2040, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition.
At the inner blood retina barrier (iBRB), claudin-5 is the most enriched component of the tight junctions of endothelial cells, regulating the paracellular diffusion of molecules into and out of the retina. As part of the on-going ERC Consolidator grant Retina-Rhythm, we now have a very large body of data suggesting “leaky” or “CLDN-5 depleted” retinal vasculature drives the accumulation of waste material known as drusen, the hallmark diagnostic feature of AMD. Therefore, methods aimed at enhancing CLDN-5 expression can potentially stabilize vascular integrity and prevent the onset of AMD (both dry and wet AMD). Here, we will develop novel adeno-associated viruses (AAV) that will directly regulate the expression of 2 novel target genes and effectively ""seal"" the blood retina barrier and stabilise disease progression."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health sciencesclinical medicineophthalmology
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Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsHost institution
D02 CX56 Dublin
Ireland