Objective
The consumption of mycotoxin-contaminated commodities is related to several acute and chronic diseases in humans. Consumer pressure in Europe has resulted in efforts to find effective natural compounds to substitute existing food grade preservatives to control the growth of mycotoxigenic food spoilage moulds. In this project the research of the functional relationship between natural anti-fungals, direct impact on the key mycotoxin clusters genes as well as relating this to phenotypic mycotoxin production will facilitate the understanding of their differential mechanisms of action. A limited number of antifungal natural compounds have shown good efficacy against mycotoxigenic spoilage moulds (Penicillium, Aspergillus and Fusarium). However, inhibition of mycotoxin production is affected by environmental conditions and in some cases low levels of these compounds have been found to stimulate mycotoxins production (ochratoxin, deoxynivalenol, fumonisins). This study will use multidisciplinary tools at a molecular, cellular, fungal morphology and colony structure level, to understand the differential way of action of fungistatics and fungicides against key mycotoxigenic species under different environmental regimes. Techniques as LC-MS, RT-PCR, fluorescence staining and analysis by confocal microscopy and flow cytometry, will be applied. The results generated will provide a method for better understanding the mechanisms of action as well as providing guidelines for the best GRAS chemicals to use under different environmental condition to prevent contamination by such natural toxins.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MK43 0AL Cranfield - Bedfordshire
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.