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The role of necrotrophic effectors in the ability of Botrytis and Monilinia species to infect host plants

Objective

Botrytis cinerea and Monilinia fructicola are both devastating pathogens that can cause decay in a broad range of hosts during pre and postharvest handling. Despite the current use of chemical fungicides, both fungal pathogens are still responsible of important economic losses worldwide. The knowledge of pathogen virulence mechanisms is an important step to guide the search for new control strategies alternative to the fungicides currently in use. Crucially, the genome sequences of both B. cinerea and M. fructicola can be exploited to identify genes and proteins that determine their ability to infect host plants. By applying molecular and bioinformatic analysis, NECROFUNGI aims to identify genes that encode necrotrophic effector proteins which only kill their specific host, but do not affect other plant species. The identification of genes responsible for disease will lead the way towards new strategies to control plant diseases based on the development of new classes of chemicals that are not directly toxic to fungi and to design more efficient breeding strategies. Wageningen University has an extraordinary resource to carry out this research. The host will train Dr. Vilanova in molecular and bioinformatic techniques in the study of the B. cinerea and M. fructicola genomes, providing the necessary skills for her to establish a similar facility in her home country in the study of M. fructicola where none currently exists. In turn, the fellow will bring specific expertise in postharvest fruit-pathogen interactions, not currently available at the host institution. The multidisciplinary perspective adopted, combining fruit-pathology, comparative genomics, molecular biology and bioinformatics will build the necessary information to control these two devastating pathogens by effector-based technologies that would provide a great economic benefit for EU agriculture.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2016

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Coordinator

WAGENINGEN UNIVERSITY
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 177 598,80
Address
DROEVENDAALSESTEEG 4
6708 PB Wageningen
Netherlands

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 177 598,80
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