Objective
Alzheimer’s disease (AD) is a major public health problem with substantial economical and social impacts worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Under homeostasis, a delicate balance is struck between disposal of pathogenic proteins by the brain’s immune cells, microglia, and the inflammation produced by these cells. Indeed, during an acute activation, microglia are protective, but if microglia enter an over-activated state they can induce chronic inflammation through oxidative stress that in turn leads to neuronal damage. Thus, gaining data on the chain of events involved in microglial action is a prerequisite to understanding AD. This project is a large interdisciplinary collaborative effort involving well-established methods such as confocal imaging and transgenic zebrafish, with newly developed photopharmacological tools. Drs Kettunen, Grøtli and Andréasson provide the world-leading expertise required for the project. By coordinating this project, Dr Mourabit will gain invaluable experience in biomedical research, photochemistry, project management, supervision, and the production of scientific results. The novel photoresponsive probes used here will allow for photonic in vivo de/activation of microglia, generating new information on their spatiotemporal activity, in real-time. This state-of-the-art resolution of cell-tracking and control of microglial signalling will provide innovative data on the pathology of neuroinflammation. We believe this interdisciplinary team will push the boundaries of research in AD. This project has the potential to identify new treatments for AD, and influence the direction of neurobiology. This project will create a unique career opportunity for Dr Mourabit, enabling him to crossover from an environmental background to biomedical research. The marrying of such interconnected disciplines will help Dr Mourabit set the foundations of an eclectic and vibrant research group.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences health sciences public health
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine immunology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.