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Innovative in-line Raman analytical sensor for new upstream cell culture monitoring and quality control

Objective

The main objective of the CellUp business innovation project is to develop and commercialize the new disruptive in-line
analytics sensor for upstream cell culture process that the biopharmaceutical industry needs for the quality and process
control during the phases of process development, scale-up and manufacturing of vaccines and antibodies for human
medicines based on eukaryote cells culture.
This new bioprocess analyser will be the first industrial sensor able to perform in-line quantification of the main nutrients and
metabolites during the mammalian cell culture inside the bioreactor.
Today, cell cultures in bioreactors are only monitored in real time with temperature, PH and Oxygen density sensors. The
negative consequences of such a limited control are huge in terms of batch failures, time consumed at each scale-up phase
and in terms of untapped production yield improvement.
Our company, with its unique integrated SWIFTS technology has the opportunity to fix the above described problem by
offering a high performance miniaturized in-line Raman analyzer which can be implemented as an industrial GMP sensor.
Based on the needs expressed by several major industrial actors, the company has already developed a first product
successfully evaluated and released end of 2016 under the name ProCellics.
The objective of the CellUp project is to go a step further in the integration of the Raman analyser thanks to a new
configuration of our technology, called SWITS-CD. We will also develop a new “standard addition method” technology and a
related software to provide an easy and robust way to implement the monitoring of the cell culture. The key to the success of
this new methodology development is a cell culture activity carried internally by our company.
The total accessible market is estimated at 750 M€ for a first equipment of the 20,000 biopharma industry bioreactors, allowing the emergence of a European leader with more than 300 job creation over 10 years.

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Programme(s)

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Topic(s)

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Funding Scheme

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SME-2 - SME instrument phase 2

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-SMEInst-2016-2017

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Coordinator

RESOLUTION SPECTRA SYSTEMS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 969 553,75
Address
13 CHEMIN DU VIEUX CHENE
38240 MEYLAN
France

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 969 553,75
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