Objective
The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large rely upon switching of individual components to carry out their functions—and the machines of the macroscopic world, which utilize the synchronized behaviour of integrated components to perform tasks more complex than the sum of the components. The aim of this project is to learn how to integrate the movements and chemistries of different molecular machine components.
The proposed program is divided into three themes:
Theme 1: Transport and synthesis by nanomechanical substrate positioning. We will integrate switching mechanisms with components that can attach and release a substrate, in order to develop methodology for the nanomechanical manipulation of substrates. We see this theme as reminiscent of the way that substrates are passed between sites in various enzyme complexes in biology.
Theme 2: Sequence-selective synthesis using molecular assembly lines. We will integrate reactive molecular appendages with rotaxanes in which the macrocycle moves along a track through brownian motion, in order to develop molecular assembly lines. This theme is reminiscent of molecular-machine-mediated sequence specific polymerisation in biology, such as protein synthesis by the ribosome and DNA synthesis by some DNA polymerases.
Theme 3: Transport with chemically fuelled molecular linear motors. We shall integrate ratchet mechanisms with chemically fuelled molecular pumps and walkers and use them to transport cargo between phases and to carry out synthesis via energy ratchet mechanisms induced by chemical fuels. This theme is reminiscent of how biological molecular motors drive chemical systems away from equilibrium, thereby enabling tasks to be performed, cargo to be transported directionally and work to be done.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.