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Training European Experts in Inflammation: from the molecular players to animal models and the bedside

Project description

Understanding inflammatory processes

Inflammatory diseases represent a significant burden for western societies, having a major impact on quality of life and increasing healthcare costs. Accelerating anti-inflammatory drug discovery and deepening insights into drug actions remains a challenge. The EU-funded INFLANET project will train 15 future experts in inflammation by combining individual research projects, collaborative efforts and interdisciplinary and intersectoral training. It will provide an innovative solution for key aspects in the inflammation domain, aiming to understand how inflammatory signals are detected, integrated by inflammasome platforms and propagated into tissues. INFLANET will employ omics approaches to elucidate the genetic bases of inflammatory disorders and advise therapeutic strategies. The project will also use advanced intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes.

Objective

INFLANET, with full support from academia and industry, will train 15 future scientific experts of inflammation through a combination of individual research projects, collaborative efforts, and interdisciplinary and intersectoral training. The prevalence of chronic inflammatory diseases in western societies is 5-7%, having a major impact on quality of life and healthcare costs. Accelerating the pace of anti-inflammatory drug discovery and deepening insights into drug actions poses a formidable challenge. This requires a comprehensive understanding of inflammatory processes, allowing us to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The ultimate goal of INFLANET is to provide innovative solutions for key bottlenecks in the inflammation field. To this end, we aim to:
(1) Understand how inflammatory signals are detected, integrated by inflammasome platforms, and propagated into tissues
(2) Take omics approaches to elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies
(3) Use cutting-edge intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes, and anti-inflammatory drugs actions
(4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disorders
Our unique training approach will unite scientists from very different fields of biology, including structural biologists, bioimagers, immunologists, and geneticists, with mathematicians, programmers and modellers. Moreover, our intersectoral training will foster business thinking and entrepreneurship. Together, INFLANET will deliver a complete curriculum for the next generation inflammation scientists, mastering phenomenological understanding, medical imaging, high content screening and therapeutic strategies.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

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Call for proposal

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(opens in new window) H2020-MSCA-ITN-2020

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Coordinator

UNIVERSITE DE MONTPELLIER
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 824 406,12
Address
163 RUE AUGUSTE BROUSSONNET
34090 Montpellier
France

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Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 824 406,12

Participants (12)

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