Objective
Darwin in the Origin of Species laid the foundations of modern evolutionary biology on two central ideas: (i) all species are related to each other through a history of common descent, and (ii) the delicate match between a species and its environment is explained by natural selection. These two ideas embody the duality of pattern and process that is a fundamental feature of the evolution of life on earth: the unique historic pattern of descent and the interplay of population genetic and genomic processes that have generated it.
In the proposed research I plan to undertake the reconstruction of the historic pattern of genome evolution across a broad phylogenetic range encompassing the three domains of life. I aim to reconstruct the prevailing trend of genomic descent (the tree of genomes) together with inference of the genomic process that relate it to the histories of its constituent parts (the forest of gene trees). Explicitly considering these processes, i.e. the history of gene transfers, duplications and losses will permit the use of complete genomes, instead of a handful of genes. The proposed large scale reconstruction will also enable the development of a valuable database of gene transfer, duplication and loss events that could potentially benefit a wide range of biological research. I will use this database to investigate the role of horizontal gene transfer (HGT) in genomic innovation, and ask questions about the biochemical, regulatory and ecological opportunities and constraints that govern the process of gene acquisition and loss that gave rise to the observed phylogenetic pattern of HGT.
During the course of the fellowships I will be able to use my experience in developing quantitative evolutionary models and preforming Monte Carlo simulations in an entirely new setting. I expect to obtain extensive experience at both the theoretical level, in evolutionary genomics and phylogenetic inference, as well as at the methodological level, in handling la
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biological morphology comparative morphology
- natural sciences computer and information sciences databases
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.