Objective
"Background: The human micro- and macrocirculation have distinct vital roles in the homeostasis of the cardiovascular system. There is a cross-talk between the two circuits to achieve the adequate vascular adaptations. Reciprocal transduction of ills signal between the micro- and macrocirculation may impair their optimal coupling and further accelerate vascular disease. In Europe the prevalence of insulin resistance (IR) (obesity and diabetes type 2) states and the related vascular damage and mortality is increasing rapidly. Main Scientific objective: to identify the early events in the natural history of chronic vascular disease of the micro- and macrocirculation in IR states and to investigate of the adaptive process of each circuit to the other in order to maintain optimal coupling. Specific scientific objectives: investigation of the cross-talk between wave reflections, pressure amplification, blood pressure phenotypes and blood flow patterns (conduit arteries, skin, muscle, retina) and their relation to the function and structure of large/small arteries, arterioles and cappilaries, endothelial function. Main training Objective: trained-through-research under supervision and hands-on training on microcirculation novel techniques; supervision of the investigations on macrocirculation. Study design: observational, population-based cross sectional study. Study population: random sample (1200 subjects) of Maastricht's area population with and without IR states, age 40-75. Microcirculation: skin videomicroscopy, retinamicroscopy, skin laser doppler and fourier analyses, muscle contrast-enhanced ultrasound,Macrocirculation: pulse wave analysis (mathematic applications-wave separation analysis), pulse wave velocity, carotid/brachial ultrasound, Other methods: All participants will be phenotyped by means of questionnaire, biood, urine, anthropometry, electrocardiogran and echocardiography.
Expected results: to identify the very early events and the adaptive processes"
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6200 MD Maastricht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.