Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes

Informacje na temat projektu

INDEX

Identyfikator umowy o grant: 766466

DOI

10.3030/766466

Projekt został zamknięty

Data podpisania przez KE 8 Sierpnia 2017

Data rozpoczęcia 1 Października 2017

Data zakończenia 31 Marca 2021

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 2 983 525,00

Wkład UE

€ 2 982 275,00

Koordynowany przez

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Project dedicated web site

Publishing of the project dedicated website.

Open Research Data Pilot (2)

Data management plan

Generation of a Data Management Plan to follow the Horizon 2020 Open Research Data Pilot guidelines

Updated data management plan

Update of the Data Management Plan

Documents, reports (5)

Intermediate dissemination and exploitation report

This document will report on the plan envisaged by the consortium for project results dissemination and exploitation

Report on exosome-specific Ab selection

This document will report on the selection of the panel of antibodies for on-chip exosome immuno- phenotyping

Final dissemination and exploitation report

This document will report on the dissemination activities held during the project and on the possibility of exploitation of results and deliverables for translation of inventions obtained during the project.

Report on clinical demonstration

This document will report on the results obtained using the newly developed instrumentation with selected clinical samples

Report on criteria for system demonstration

This report will provide the specifications on the requested performance of the systems and the criteria that will be used for system demonstration at the end of the project.

Publikacje

Other (6)

Computational nanosensing from defocus in single particle interferometric reflectance microscopy

Autorzy: Yurdakul, C., M.S., Ünlü
Opublikowane w: OpticsLetters, 2020
Wydawca: OpticsLetters
DOI: 10.1364/ol.409458

Separation of Extracellular Vesicles by DNA-Directed Immunocapturing Followed by Enzymatic Release

Autorzy: Brambilla, D., Sola, L., Chiodi, E., Zarovni, N., Fortunato, D., Criscuoli, M., Dolo, V., Giusti, I., Murdica, V., Vago, R., Chiari, M.
Opublikowane w: ChemRxiv, 2020
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv.12234683.v1

Multiplexed affinity measurements of extracellular vesicles binding kinetics

Autorzy: Chiodi, E.; Daaboul, G.; Marn, A.M.; Ünlü, M.S.
Opublikowane w: ChemRxiv, 2021
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv.13547459.v1

A Bi-Functional Polymeric Coating for the Co-Imobilization of Proteins and Peptides on Microarray Substrates

Autorzy: Laura Sola, Dario Brambilla, Alessandro Mussida, Roberto Consonni, Francesco Damin, Marina Cretich, Alessandro Gori, Marcella Chiari
Opublikowane w: ChemRxiv, 2020
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv.13135769.v1

Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging.

Autorzy: Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; Ünlü, M. Selim; et al.
Opublikowane w: Chemrxiv, 2019
Wydawca: Chemrxiv
DOI: 10.26434/chemrxiv.8976347.v1

Advantageous Antibody Microarray Fabrication Through DNA-Directed Immobilization: A Step Toward Use of Extracellular Vesicles in Diagnostics

Autorzy: Dario Brambilla; Laura Sola; Marcella Chiari
Opublikowane w: Chemrxiv, Numer 1, 2020
Wydawca: Chemrxiv
DOI: 10.26434/chemrxiv.12227255.v1

Peer reviewed articles (11)

Author Correction: Label-free detection of nanoparticles using depth scanning correlation interferometric microscopy

Autorzy: Ugur Aygun, Hakan Urey, Ayca Yalcin Ozkumur
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-53131-3

Small evs-associated dna as complementary biomarker to circulating tumor dna in plasma of metastatic colorectal cancer patients

Autorzy: Silvia Galbiati, Francesco Damin, Dario Brambilla, Lucia Ferraro, Nadia Soriani, Anna Maria Ferretti, Valentina Burgio, Monica Ronzoni, Riccardo Vago, Laura Sola. Marcella Chiari,
Opublikowane w: Pharmaceuticals, 2021, ISSN 1424-8247
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14020128

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

Autorzy: Roberto Frigerio, Angelo Musicò, Marco Brucale, Andrea Ridolfi, Silvia Galbiati, Riccardo Vago, Greta Bergamaschi, Anna Ferretti, Marcella Chiari, Francesco Valle, Alessandro Gori, Marina Cretich
Opublikowane w: Cells 2021, Numer 10, 2021, Strona(/y) 544, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10030544

High-Throughput, High-Resolution Interferometric Light Microscopy of Biological Nanoparticles

Autorzy: Celalettin Yurdakul, Oguzhan Avci, Alex Matlock, Alexander J. Devaux, Maritza V. Quintero, Ekmel Ozbay, Robert A. Davey, John H. Connor, W. Clem Karl, Lei Tian, M. Selim Ünlü
Opublikowane w: ACS Nano, Numer 14/2, 2020, Strona(/y) 2002-2013, ISSN 1936-0851
Wydawca: American Chemical Society
DOI: 10.1021/acsnano.9b08512

The Role of Surface Chemistry in the Efficacy of Protein and DNA Microarrays for Label-Free Detection: An Overview

Autorzy: Elisa Chiodi, Allison M. Marn, Matthew T. Geib, M. Selim Ünlü
Opublikowane w: Polymers, Numer 13/7, 2021, Strona(/y) 1026, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13071026

Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations

Autorzy: Galbiati, Damin, Ferraro, Soriani, Burgio, Ronzoni, Gianni, Ferrari, Chiari
Opublikowane w: Cells, Numer 8/8, 2019, Strona(/y) 769, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells8080769

Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Autorzy: Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari
Opublikowane w: PLOS ONE, Numer 13/12, 2018, Strona(/y) e0207876, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0207876

Membrane‐binding peptides for extracellular vesicles on‐chip analysis

Autorzy: Alessandro Gori, Alessandro Romanato, Greta Bergamaschi, Alessandro Strada, Paola Gagni, Roberto Frigerio, Dario Brambilla, Riccardo Vago, Silvia Galbiati, Silvia Picciolini, Marzia Bedoni, George G. Daaboul, Marcella Chiari, Marina Cretich
Opublikowane w: Journal of Extracellular Vesicles, Numer 9/1, 2020, Strona(/y) 1751428, ISSN 2001-3078
Wydawca: Taylor&Francis
DOI: 10.1080/20013078.2020.1751428

Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays

Autorzy: Greta Bergamaschi, Enrico M. A. Fassi, Alessandro Romanato, Ilda D'Annessa, Maria Teresa Odinolfi, Dario Brambilla, Francesco Damin, Marcella Chiari, Alessandro Gori, Giorgio Colombo, Marina Cretich
Opublikowane w: International Journal of Molecular Sciences, Numer 20/8, 2019, Strona(/y) 1921, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20081921

A Reliable, Label Free Quality Control Method for the Production of DNA Microarrays with Clinical Applications

Autorzy: Elisa Chiodi, Francesco Damin,*,Laura Sola*, Lucia Ferraro, Dario Brambilla, M. Selim Ünlü and Marcella Chiari
Opublikowane w: Polymers, 2021, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13030340

Interferometric Detection and Enumeration of Viral Particles using Si-Based Microfluidics

Autorzy: Ayca Yalcin Ozkumur, Fulya Ekiz Kanik, Jacob T. Trueb, Celalettin Yurdakul, M. Selim Unlu
Opublikowane w: IEEE Journal of Selected Topics in Quantum Electronics, Numer 25/1, 2019, Strona(/y) 1-7, ISSN 1077-260X
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2018.2854548

Non-peer reviewed articles (1)

High-visibility detection of exosomes by interferometric reflectance imaging

Autorzy: Unlu, Selim; Yurdakul, Celalettin; Yalcin-Ozkumur, Ayca; Chiari, Marcella; Ekiz-Kanik, Fulya; et al.
Opublikowane w: Journal of Extracellular Vesicles, 2018, Strona(/y) 248, ISSN 2001-3078
Wydawca: Taylor&Francis

Prawa własności intelektualnej

Patent (1)

METHOD FOR THE ISOLATION OF INTACT EXTRACELLULAR VESICLES

Numer wniosku/publikacji: 20 200476
Data: 2020-10-07
Wnioskodawca/wnioskodawcy: CONSIGLIO NAZIONALE DELLE RICERCHE