Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology

Informacje na temat projektu

ReCaP

Identyfikator umowy o grant: 788753

DOI

10.3030/788753

Projekt został zamknięty

Data podpisania przez KE 20 Czerwca 2018

Data rozpoczęcia 1 Sierpnia 2018

Data zakończenia 31 Lipca 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 999 410,00

Wkład UE

€ 2 999 410,00

Koordynowany przez

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (33)

Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Autorzy: Power, R.N.; Cavanagh, B.L.; Dixon, J.E.; Curtin, C.M.; O'Brien, F.J.
Opublikowane w: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031460

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Autorzy: Brady, R.T.; O'Brien, F.J.; Hoey, D.A.
Opublikowane w: Bioengineering, 2022, ISSN 2306-5354
Wydawca: MDPI
DOI: 10.3390/bioengineering9010035

Bone biomaterials for overcoming antimicrobial resistance: Advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue

Autorzy: Joanna M. Sadowska, Katelyn J. Genoud, Daniel J. Kelly, Fergal J. O'Brien
Opublikowane w: Materials Today, 2021, ISSN 1369-7021
Wydawca: Elsevier BV
DOI: 10.1016/j.mattod.2020.12.018

Translational Studies on the Potential of a VEGF Nanoparticle-Loaded Hyaluronic Acid Hydrogel

Autorzy: Joanne O’Dwyer, Robert Murphy, Arlyng González-Vázquez, Lenka Kovarova, Martin Pravda, Vladimir Velebny, Andreas Heise, Garry P. Duffy, Sally Ann Cryan
Opublikowane w: Pharmaceutics, Numer 13/6, 2021, Strona(/y) 779, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13060779

Development and in vitro investigation of a biodegradable mesh for the treatment of stress urinary incontinence

Autorzy: MacCraith, E.; Joyce, M.; do Amaral, R.FJ.C.; O'Brien F.J.; Davis, N.F.
Opublikowane w: International Urogynecology Journal, 2022, ISSN 1433-3023
Wydawca: Springer
DOI: 10.1007/s00192-022-05160-2

Collagen silver-doped hydroxyapatite scaffolds reinforced with 3D printed frameworks for infection prevention and enhanced repair of load-bearing bone defects

Autorzy: Katelyn J Genoud, Joanna M Sadowska, Rachael N Power, Lara S Costard, Emily J Ryan, Austyn R Matherson, Arlyng G Gonzalez-Vazquez, Mark Lemoine, Kian Eichholz, Pierluca Pitacco, Gang Chen, Brenton Cavanagh, Orquidea Garcia, Ciara M Murphy, Caroline M Curtin, Daniel J Kelly, Fergal J O’Brien
Opublikowane w: Biofabrication, Numer 17, 2025, Strona(/y) 025010, ISSN 1758-5082
Wydawca: IOS Press
DOI: 10.1088/1758-5090/adaf59

Highly Porous Type II Collagen-Containing Scaffolds for Enhanced Cartilage Repair with Reduced Hypertrophic Cartilage Formation

Autorzy: Intini,C.; Hodgkinson, T.; Casey S.M.; Gleeson, J.P.; O'Brien F.J.
Opublikowane w: Bioengineering, 2022, ISSN 2306-5354
Wydawca: MDPI
DOI: 10.3390/bioengineering9060232

Collagen-based 3D printed poly (glycerol sebacate) composite scaffold with biomimicking mechanical properties for enhanced cartilage defect repair

Autorzy: Yu-Yao Liu, Claudio Intini, Marko Dobricic, Fergal J. O'Brien, Javier LLorca, Monica Echeverry-Rendon
Opublikowane w: International Journal of Biological Macromolecules, Numer 280, 2024, Strona(/y) 135827, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.135827

Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms

Autorzy: Joanna M. Sadowska, Monika Ziminska, Cole Ferreira, Austyn Matheson, Auden Balouch, Jasmine Bogle, Samantha Wojda, John Redmond, Ahmed Elkashif, Nicholas Dunne, Helen O. McCarthy, Seth Donahue, Fergal J. O'Brien
Opublikowane w: Biomaterials, Numer 303, 2024, Strona(/y) 122398, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122398

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Autorzy: Mark Lemoine, Sarah M. Casey, John M. O'Byrne, Daniel J. Kelly, Fergal J. O'Brien
Opublikowane w: Biochemical Society Transactions, Numer 48/4, 2020, Strona(/y) 1433-1445, ISSN 0300-5127
Wydawca: Portland Press, Ltd.
DOI: 10.1042/bst20190938

Gene activated reinforced scaffolds for SOX9 delivery to enhance repair of large load bearing articular cartilage defects

Autorzy: M Joyce, T Hodgkinson, C Intini, JE Dixon, DJ Kelly, FJ O'Brien
Opublikowane w: European Cells and Materials, Numer 47, 2024, Strona(/y) 91-108, ISSN 1473-2262
Wydawca: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v047a07

An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects

Autorzy: Donagh G O’Shea, Tom Hodgkinson, Caroline M Curtin, Fergal J O’Brien
Opublikowane w: Biofabrication, Numer 16, 2023, Strona(/y) 015007, ISSN 1758-5082
Wydawca: IOS Press
DOI: 10.1088/1758-5090/ad047a

Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing

Autorzy: Eamon J. Sheehy, Gregory J. Miller, Isabel Amado, Rosanne M. Raftery, Gang Chen, Kai Cortright, Arlyng Gonzalez Vazquez, Fergal J. O'Brien
Opublikowane w: Journal of Controlled Release, Numer 334, 2021, Strona(/y) 96-105, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2021.03.031

An Innovative miR‐Activated Scaffold for the Delivery of a miR‐221 Inhibitor to Enhance Cartilage Defect Repair

Autorzy: Claudio Intini, Lia Blokpoel Ferreras, Sarah Casey, James E. Dixon, John P. Gleeson, Fergal J. O'Brien
Opublikowane w: Advanced Therapeutics, Numer 6, 2023, ISSN 2366-3987
Wydawca: Wiley
DOI: 10.1002/adtp.202200329

The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis

Autorzy: Hodgkinson, T.; Amado, I.N.; O'Brien F.J.; Kennedy, O.D.
Opublikowane w: APL Bioengineering, 2021, ISSN 1077-3118
Wydawca: AIP Publishing
DOI: 10.1063/5.0068277

A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair

Autorzy: Shan An, Claudio Intini, Donagh O'Shea, James E. Dixon, Yiran Zheng, Fergal J. O'Brien
Opublikowane w: Materials Today Bio, Numer 30, 2025, Strona(/y) 101382, ISSN 2590-0064
Wydawca: Elsevier
DOI: 10.1016/j.mtbio.2024.101382

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Autorzy: Levingstone, T.J.; Sheehy E.J.; Moran, C.J.; Cunniffe, G.M.; Diaz Payno, P.J.; Brady, R.T.; Almeida, H.V.; Carroll, S.F.; Byrne, J.O'M.; Kelly, D.J.; Brama, P.A.J.; O'Brien F.J.
Opublikowane w: Biomaterials and Biosystems, 2022, ISSN 2666-5344
Wydawca: Elsevier
DOI: 10.1016/j.bbiosy.2022.100066

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Autorzy: Lara S. Costard, Domhnall C. Kelly, Rachael N. Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L. Cavanagh, Caroline M. Curtin, Fergal J. O’Brien
Opublikowane w: Pharmaceutics, Numer 12/12, 2020, Strona(/y) 1219, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12121219

Rapid bone repair with the recruitment of CD206+M2-like macrophages using non-viral scaffold-mediated miR-133a inhibition of host cells

Autorzy: Irene Mencía Castaño, Rosanne M. Raftery, Gang Chen, Brenton Cavanagh, Brian Quinn, Garry P. Duffy, Fergal J. O'Brien, Caroline M. Curtin
Opublikowane w: Acta Biomaterialia, Numer 109, 2020, Strona(/y) 267-279, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2020.03.042

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Autorzy: William A. Lackington, Maria Antonia Gomez-Sierra, Arlyng González-Vázquez, Fergal J. O’Brien, Martin J. Stoddart, Keith Thompson
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 8, 2020, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2020.582012

Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

Autorzy: Rosanne M. Raftery, Arlyng G. Gonzalez Vazquez, Gang Chen, Fergal J. O'Brien
Opublikowane w: Advanced Healthcare Materials, Numer 9/10, 2020, Strona(/y) 1901827, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901827

Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects

Autorzy: M Joyce, T Hodgkinson, M Lemoine, A González-Vázquez, DJ Kelly, FJ O’Brien
Opublikowane w: European Cells and Materials, Numer 45, 2023, Strona(/y) 158-172, ISSN 1473-2262
Wydawca: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a11

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3

Autorzy: Arlyng González-Vázquez, Rosanne M. Raftery, Suzan Günbay, Gang Chen, Dylan J. Murray, Fergal J. O'Brien
Opublikowane w: Biomaterials, Numer 268, 2021, Strona(/y) 120540, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120540

Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing

Autorzy: Yang Liu, Manoj Puthia, Eamon J. Sheehy, Ines Ambite, Jitka Petrlova, Sujeethkumar Prithviraj, Maria Wimer Oxborg, Sujeesh Sebastian, Corina Vater, Stefan Zwingenberger, André Struglics, Paul E. Bourgine, Fergal J. O'Brien, Deepak Bushan Raina
Opublikowane w: Acta Biomaterialia, Numer 162, 2023, Strona(/y) 164-181, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2023.03.028

Interleukin-1 receptor antagonist enhances the therapeutic efficacy of a low dose of rhBMP-2 in a weight-bearing rat femoral defect model

Autorzy: William A. Lackington, Dominic Gehweiler, Ensi Zhao, Ivan Zderic, Dirk Nehrbass, Stephan Zeiter, Arlyng González-Vázquez, Fergal J. O'Brien, Martin J. Stoddart, Keith Thompson
Opublikowane w: Acta Biomaterialia, Numer 149, 2024, Strona(/y) 189-197, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2022.07.012

A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition

Autorzy: Intini, C.; Lemoine, M.; Hodgksinon, T.; Casey, S.M.; Gleeson, J.P.; O'Brien F.J.
Opublikowane w: Biomaterials Science, 2022, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1bm01417j

Incorporation of hydroxyapatite into collagen scaffolds enhances the therapeutic efficacy of rhBMP-2 in a weight-bearing femoral defect model

Autorzy: Lackington, W.A.; Gehweiler, D.; Zderic, I.; Nehrbass, D.; Zeitar, S.; Gonzalez-Vazquez, A.; O'Brien, F.J.; Stoddart, M.J.; Thopmpson, K.
Opublikowane w: Materials Today Communications, 2021, ISSN 2352-4928
Wydawca: Elsevier BV
DOI: 10.1016/j.mtcomm.2021.102933

A Multifunctional Scaffold for Bone Infection Treatment by Delivery of microRNA Therapeutics Combined With Antimicrobial Nanoparticles

Autorzy: Joanna M. Sadowska, Rachael. N. Power, Katelyn J. Genoud, Austyn Matheson, Arlyng González‐Vázquez, Lara Costard, Kian Eichholz, Pierluca Pitacco, Tanguy Hallegouet, Gang Chen, Caroline M. Curtin, Ciara M. Murphy, Brenton Cavanagh, Huijun Zhang, Daniel J. Kelly, Aldo R. Boccaccini, Fergal J. O'Brien
Opublikowane w: Advanced Materials, Numer 36, 2024, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202307639

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications

Autorzy: Katie McCormick, Jorge Moreno Herrero, Heinrich Haas, Sarinj Fattah, Andreas Heise, Fergal J. O’Brien, Sally-Ann Cryan
Opublikowane w: Molecular Pharmaceutics, Numer 21, 2024, Strona(/y) 1662-1676, ISSN 1543-8384
Wydawca: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.3c00898

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Autorzy: Tom Hodgkinson, P. Monica Tsimbouri, Virginia Llopis-Hernandez, Paul Campsie, David Scurr, Peter G. Childs, David Phillips, Sam Donnelly, Julia A. Wells, Fergal J. O’Brien, Manuel Salmeron-Sanchez, Karl Burgess, Morgan Alexander, Massimo Vassalli, Richard O. C. Oreffo, Stuart Reid, David J. France, Matthew J. Dalby
Opublikowane w: Science Advances, Numer 7/9, 2021, Strona(/y) eabb7921, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.abb7921

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

Autorzy: O'Shea, D.G.; Curtin C.M.; O'Brien F.J.
Opublikowane w: Biomaterials Science, 2022, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1bm01540k

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

Autorzy: Hodgkinson, T.; Kelly, D.C.; Curtin, C.M.; O'Brien F.J.
Opublikowane w: Nature Reviews Rheumatology, 2021, ISSN 1759-4804
Wydawca: Nature Publishing Group
DOI: 10.1038/s41584-021-00724-w

Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models

Autorzy: Arlyng G. González Vázquez, Lia A. Blokpoel Ferreras, Kathleen E. Bennett, Sarah M. Casey, Pieter AJ Brama, Fergal J. O'Brien
Opublikowane w: Advanced Healthcare Materials, 2021, ISSN 2192-2659
Wydawca: World Scientific
DOI: 10.1002/adhm.202100878

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