Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Report on the monitoring strategy adopted
Report on SOPs and templates

Project Website
Project clip

Publikacje

Plasma proteins elevated in severe asthma despite oral steroiduse and unrelated to Type-2 inflammation

Autorzy: Maria Sparreman Mikus, Johan Kolmert, Lars I. Andersson, Jörgen Östling, Richard G. Knowles, Cristina Gómez, Magnus Ericsson, John-Olof Thörngren, Payam Emami Khoonsari, Barbro Dahlén, Maciej Kupczyk, Bertrand De Meulder, Charles Auffray, Per S. Bakke, Bianca Beghe, Elisabeth H. Bel, Massimo Caruso, Pascal Chanez, Bo Chawes, Stephen J. Fowler, Mina Gaga, Thomas Geiser, Mark Gjomarkaj, Ildikó
Opublikowane w: European Respiratory journal, Numer 13993003, 2022, ISSN 1399-3003
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.00142-2021

A cluster of blood-based protein biomarkers associated with decreased cerebral blood flow relates to future cardiovascular events in patients with cardiovascular disease

Autorzy: L Malin Overmars, Sanne Kuipers, Bram van Es, Jeroen de Bresser, Esther E Bron, Imo E Hoefer, Wouter W Van Solinge, L Jaap Kappelle, Matthias JP van Osch, Charlotte E Teunissen, Geert Jan Biessels, Saskia Haitjema, null null
Opublikowane w: Journal of Cerebral Blood Flow & Metabolism, Numer 43, 2024, Strona(/y) 2060-2071, ISSN 0271-678X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x231195243

Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus: implications for anti-LIN28A, anti-HMGN5, anti-IRF5, and anti-TGIF1

Autorzy: Julius Lindblom, Denis Lagutkin, Natalia Sherina, Helena Idborg, Lorenzo Beretta, Maria Orietta Borghi, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Ana Tavares, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ignasi Rodríguez-Pintó, Gerard Espin
Opublikowane w: Annals of the Rheumatic Diseases, Numer 84, 2025, Strona(/y) 1164-1179, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.04.008

Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Autorzy: Khaleva, Ekaterina; Rattu, Anna; Brightling, Chris; Bush, Andrew; Bossios, Apostolos; Bourdin, Arnaud; Chung, Kian Fan; Chaudhuri, Rekha; Coleman, Courtney; Dahlén, Sven Erik; Djukanovic, Ratko; Deschildre, Antoine; Fleming, Louise; Fowler, Stephen J.; Gupta, Atul; Hamelmann, Eckard; Hashimoto, Simone; Hedlin, Gunilla; Koppelman, Gerard H.; Melén, Erik; Murray, Clare S.; Pilette, Charles; Porsbj
Opublikowane w: EUROPEAN RESPIRATORY JOURNAL, Numer 5, 2023, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.00606-2022

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Autorzy: Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, null null, P. Carreira, I. Castellvi, R. Ríos, R. García Portales, A. Fernández-Nebro, F. J. García-Hernández, M. A. Aguirre, B. Fernández-Gutiérrez, L. Rodríguez-Rodríguez, P. García de la Peña, E. Vicente, J. L. Andreu, M. Fernández de Castro, F. J. López-Longo, V. Fonollosa,
Opublikowane w: npj Genomic Medicine, Numer 7, 2023, ISSN 2056-7944
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41525-022-00327-8

Response to the letter ‘testing the effectiveness of MyPROSLE in classifying patients with lupus nephritis’

Autorzy: Daniel Toro-Domínguez, Jordi Martorell-Marugán, Manuel Martinez-Bueno, Raúl López-Domínguez, Elena Carnero-Montoro, Guillermo Barturen, Daniel Goldman, Michelle Petri, Pedro Carmona-Sáez, Marta E Alarcón-Riquelme
Opublikowane w: Briefings in Bioinformatics, Numer 25, 2023, ISSN 1467-5463
Wydawca: Oxford University Press
DOI: 10.1093/bib/bbad454

Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus

Autorzy: Julius Lindblom, Daniel Toro-Domínguez, Elena Carnero-Montoro, Lorenzo Beretta, Maria Orietta Borghi, Jessica Castillo, Yvonne Enman, PRECISESADS Clinical Consortium, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Ioannis Parodis
Opublikowane w: Journal of Autoimmunity Volume 136, April 2023, 103025, 2023, ISSN 1095-9157
Wydawca: Elsevier
DOI: 10.1016/j.jaut.2023.103025

Predicting corticosteroid response in COPD using baseline bronchial biopsy DNA methylation

Autorzy: Tessa E. Gillett, Corry-Anke Brandsma, Alen Faiz, Wim Timens, Gerard H. Koppelman, Martijn C. Nawijn, Maarten van den Berge
Opublikowane w: ERJ Open Research, Numer 11, 2025, Strona(/y) 00724-2024, ISSN 2312-0541
Wydawca: European Respiratory Society (ERS)
DOI: 10.1183/23120541.00724-2024

New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity–could anti-LIN28A enhance precision in diagnostics?

Autorzy: Ioannis Parodis, Denis Lagutkin, Julius Lindblom, Helena Idborg, Lorenzo Beretta, Maria Orietta Borghi, Janique M. Peyper, Guillermo Barturen, Per-Johan Jakobsson, Marta E. Alarcón-Riquelme, Natalia Sherina, Dionysis Nikolopoulos
Opublikowane w: Annals of the Rheumatic Diseases, Numer 84, 2025, Strona(/y) 1180-1194, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.04.003

Core outcome sets, developed collaboratively with patients, can improve the relevance and comparability of clinical trials

Autorzy: Alexander G. Mathioudakis, Ekaterina Khaleva, Markus Fally, Paula R. Williamson, Jens-Ulrik Jensen, Tim W. Felton, Chris Brightling, Andrew Bush, Tonya Winders, John Linnell, Valeria Ramiconi, Courtney Coleman, Tobias Welte, Graham Roberts, Jørgen Vestbo
Opublikowane w: ERS Journal, 2023, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.02107-2022

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease

Autorzy: Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena
Opublikowane w: Nature Communications, Numer 14, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-40156-6

FixNCut: single-cell genomics through reversible tissue fixation and dissociation

Autorzy: Laura Jiménez-Gracia, Domenica Marchese, Juan C. Nieto, Ginevra Caratù, Elisa Melón-Ardanaz, Victoria Gudiño, Sara Roth, Kellie Wise, Natalie K. Ryan, Kirk B. Jensen, Xavier Hernando-Momblona, Joana P. Bernardes, Florian Tran, Laura Katharina Sievers, Stefan Schreiber, Maarten van den Berge, Tessa Kole, Petra L. van der Velde, Martijn C. Nawijn, Philip Rosenstiel, Eduard Batlle, Lisa M. Butler
Opublikowane w: Genome Biology, Numer 25, 2024, ISSN 1474-760X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s13059-024-03219-5

Characterization of Inflammatory Bowel Disease Heterogeneity Using Serum Proteomics: A Multicenter Study

Autorzy: Benita Salomon, Padhmanand Sudhakar, Daniel Bergemalm, Erik Andersson, Olle Grännö, Marie Carlson, Charlotte R H Hedin, Johan D Söderholm, Lena Öhman, null null, Ryan C Ungaro, Konrad Aden, Geert D’Haens, Mark S Silverberg, Sven Almer, Francesca Bresso, Adam Carstens, Mauro D’Amato, Carl Eriksson, Henrik Hjortswang, Åsa V Keita, Maria Ling Lundström, Maria K Magnusson, Jóhann P Hreinsso
Opublikowane w: Journal of Crohn's and Colitis, Numer 2024, XX, 1–12, 2024, ISSN 1873-9946
Wydawca: Elsevier Science
DOI: 10.1093/ecco-jcc/jjae169

POS0030 Exploring the clinical and social determinants of multiple drug failures in refractory rheumatoid arthritis

Autorzy: Y. Tan, M. Parkes, D. Plant, M. Buch
Opublikowane w: Annals of the Rheumatic Diseases, Numer 84, 2025, Strona(/y) 345, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1016/j.ard.2025.05.427

Characterization of the SPIRITAS: A Disposable Sampling Setup for Volatile Organic Compound Collection and Analysis

Autorzy: David J. Mager, Yoni E. van Dijk, Özgü Varan, Susanne J. H. Vijverberg, Suzanne W. J. Terheggen-Lagro, Anke-Hilse Maitland-van der Zee, Hettie M. Janssens, Paul Brinkman
Opublikowane w: Separations, Numer 11, 2025, Strona(/y) 150, ISSN 2297-8739
Wydawca: MDPI Open Access Journals
DOI: 10.3390/separations11050150

Transcription Factor Activity Inference in Systemic Lupus Erythematosus

Autorzy: Raúl López-Domínguez, Daniel Toro-Domínguez, Jordi Martorell-Marugan, Adrian García-Moreno, Christian H. Holland, Julio Saez-Rodriguez, Daniel Goldman, Michelle Petri, Marta E. Alarcón-Riquelme and Pedro Carmona-Sáez
Opublikowane w: Life, Numer 20751729, 2021, ISSN 2075-1729
Wydawca: MDPI
DOI: 10.3390/life11040299

<scp>CytoNorm</scp> 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls

Autorzy: Katrien L. A. Quintelier, Marcella Willemsen, Victor Bosteels, Joachim G. J. V. Aerts, Yvan Saeys, Sofie Van Gassen
Opublikowane w: Cytometry Part A, Numer 107, 2025, Strona(/y) 69-87, ISSN 1552-4922
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24910

Reliability of serum neurofilament light and glial fibrillary acidic protein for detecting disease activity upon discontinuation of first-line disease-modifying therapy in stable multiple sclerosis (DOT-MS)

Autorzy: W. H. Fung, M. H. J. Wessels, E. M. E. Coerver, J. de Beukelaar, W. H. Bouvy, L. R. Canta, O. H. H. Gerlach, E. Hoitsma, E. L. J. Hoogervorst, B. A. de Jong, N. F. Kalkers, Z. L. E. van Kempen, H. Lövenich, C. E. P. van Munster, B. W. van Oosten, J. Smolders, A. Vennegoor, E. M. P. E. Zeinstra, M. Barrantes-Cepas, G. Kooij, M. M. Schoonheim, B. I. Lissenberg-Witte, B. Moraal, F. Barkhof, B. M. J.
Opublikowane w: Journal of Neurology, Numer 272, 2025, ISSN 0340-5354
Wydawca: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-025-13231-9

Exploring the contribution of genetics on the clinical manifestations of systemic lupus erythematosus

Autorzy: Ruth D. Rodríguez, Marta E. Alarcón-Riquelme
Opublikowane w: Best Practice & Research Clinical Rheumatology, Numer 38, 2024, Strona(/y) 101971, ISSN 1521-6942
Wydawca: Bailliere Tindall And Cassell
DOI: 10.1016/j.berh.2024.101971

Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection?

Autorzy: Maria Sparreman Mikus, Johan Kolmert, Lars I. Andersson, Sven-Erik Dahlén, Anna James
Opublikowane w: European Respiratory Journal, Numer 60, 2025, Strona(/y) 2201795, ISSN 0903-1936
Wydawca: European Respiratory Society
DOI: 10.1183/13993003.01795-2022

Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients

Autorzy: Elisa Melón-Ardanaz, Marisol Veny, Ana M Corraliza, Victoria Gudiño, Alba Garrido-Trigo, Ángela Sanzo-Machuca, Marc Buendia, Miriam Esteller, Lisseth Robbins-Moreno, Maite Rodrigo, M Carme Masamunt, Ángel Giner, Marta Gallego, Ingrid Ordás, Agnès Fernández-Clotet, Berta Caballol, Ángel Corbí, Bram Verstockt, Severine Vermeire, Julian Panés, Elena Ricart, Azucena Salas
Opublikowane w: Journal of Crohn's and Colitis, Numer 19, 2025, ISSN 1873-9946
Wydawca: Elsevier Science
DOI: 10.1093/ecco-jcc/jjaf076

Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Autorzy: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E
Opublikowane w: American Journal of Respiratory and Critical Care Medicine, Numer 203/1, 2021, Strona(/y) 37-53, ISSN 1073-449X
Wydawca: American Thoracic Society
DOI: 10.1164/rccm.201909-1869oc

Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohort

Autorzy: Ioannis Parodis, Julius Lindblom, Guillermo Barturen, Rafaela Ortega-Castro, Ricard Cervera, Jacques-Olivier Pers, Fernanda Genre, Falk Hiepe, Maria Gerosa, László Kovács, Ellen De Langhe, Silvia Piantoni , Georg Stummvoll, Carlos Vasconcelos, Barbara Vigone, Torsten Witte; PRECISESADS Clinical Consortium; Marta E Alarcón-Riquelme, Lorenzo Beretta
Opublikowane w: Annals of the Rheumatic Diseases, 2024, ISSN 0003-4967
Wydawca: BMJ Publishing Group
DOI: 10.1136/ard-2023-224795

Definitions of non-response and response to biological therapy for severe asthma: a systematic review

Autorzy: Ekaterina Khaleva; Anna Rattu; Chris Brightling; Andrew Bush; Arnaud Bourdin; Apostolos Bossios; Kian Fan Chung; Rekha Chaudhuri; Courtney Coleman; Ratko Djukanovic; Sven-Erik Dahlén; Andrew Exley; Louise Fleming; Stephen J. Fowler; Atul Gupta; Eckard Hamelmann; Gerard H. Koppelman; Erik Melén; Vera Mahler; Paul Seddon; Florian Singer; Celeste Porsbjerg; Valeria Ramiconi; Franca Rusconi; Valenty
Opublikowane w: "ERJ Open Research, 2023, 9 (3), pp.00444-2022. ⟨10.1183/23120541.00444-2022⟩", Numer 3, 2023, ISSN 2312-0541
Wydawca: European Respiratory Society
DOI: 10.1183/23120541.00444-2022

Serum profiling identifies CCL8, CXCL13, and IL-1RA as markers of active disease in patients with systemic lupus erythematosus

Autorzy: Julius Lindblom, Lorenzo Beretta, Maria Orietta Borghi, and PRECISESADS Clinical Consortium, Marta E. Alarcón-Riquelme, Ioannis Parodis
Opublikowane w: Front Immunol, 2023, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1257085

Risankizumab in severe asthma: A Phase IIa, placebo-controlled study

Autorzy: Christopher E. Brightling, Parameswaran Nair, Renaud Louis, Dave Singh
Opublikowane w: The New England Journal of Medicine, 2021, ISSN 1533-4406
Wydawca: Massachusetts Medical Society
DOI: 10.1056/nejmoa2030880

Convert-Pheno: A software toolkit for the interconversion of standard data models for phenotypic data

Autorzy: Manuel Rueda, Ivo C Leist, Ivo G Gut
Opublikowane w: J Biomed Inform, 2024, ISSN 1532-0480
Wydawca: Elsevier
DOI: 10.1016/j.jbi.2023.104558

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

Autorzy: Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner, Anna Henning, Lina Welz, Nassim Kakavand, Maren Falk-Paulsen, Simon Imm, Finn Hinrichsen, Matthias Zilbauer, Stefan Schreiber, Arthur Kaser, Ri
Opublikowane w: Gastroenterology, Numer 159/4, 2020, Strona(/y) 1357-1374.e10, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.088

Serum glial fibrillary acidic protein in natalizumab-treated relapsing-remitting multiple sclerosis: An alternative to neurofilament light

Autorzy: Mark HJ Wessels, Zoë YGJ Van Lierop, Samantha Noteboom, Eva MM Strijbis, Johannes A Heijst, Zoé LE Van Kempen, Bastiaan Moraal, Frederik Barkhof, Bernard MJ Uitdehaag, Menno M Schoonheim, Joep Killestein, Charlotte E Teunissen
Opublikowane w: Multiple Sclerosis Journal, Numer 29, 2025, Strona(/y) 1229-1239, ISSN 1352-4585
Wydawca: SAGE Publications
DOI: 10.1177/13524585231188625

Current Insights on Biomarkers in Lupus Nephritis: A Systematic Review of the Literature

Autorzy: Leonardo Palazzo, Julius Lindblom, Chandra Mohan, Ioannis Parodis
Opublikowane w: J. Clin. Med., 2022, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11195759

Prospective trial of natalizumab personalised extended interval dosing by therapeutic drug monitoring in relapsing-remitting multiple sclerosis (NEXT-MS)

Autorzy: Alyssa A Toorop, Zoë YGJ van Lierop, Liza MY Gelissen, Elske Hoitsma, Esther MPE Zeinstra, Luuk C van Rooij, Caspar EP van Munster, Anke Vennegoor, Jop P Mostert, Beatrijs HA Wokke, Nynke F Kalkers, Erwin LJ Hoogervorst, Jeroen JJ van Eijk, Christiaan M Roosendaal, Jolijn J Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, LGF Sinnige, Mark E Kloosterziel, Edo PJ Arnoldus, Gert W va
Opublikowane w: Journal of Neurology, Neurosurgery & Psychiatry, 2023, Strona(/y) jnnp-2023-332119, ISSN 0022-3050
Wydawca: BMJ Publishing Group
DOI: 10.1136/jnnp-2023-332119

Impact of serum neurofilament light on clinical decisions in a tertiary multiple sclerosis clinic

Autorzy: Zoë YGJ van Lierop, Mark HJ Wessels, Womei ML Lekranty, Bastiaan Moraal, Sam N Hof, Laura Hogenboom, Brigit A de Jong, Nandi Meijs, Liselore A Mensing, Bob W van Oosten, Nik Sol, Zoé LE van Kempen, Lisa Vermunt, Myrthe J Willems, Eva MM Strijbis, Bernard MJ Uitdehaag, Joep Killestein, Charlotte E Teunissen
Opublikowane w: Multiple Sclerosis Journal, Numer 30, 2025, Strona(/y) 1620-1629, ISSN 1352-4585
Wydawca: SAGE Publications
DOI: 10.1177/13524585241277044

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

Autorzy: Harald Hegen, Klaus Berek, Paola Cavalla, Mikael Christiansen, Andreja Emeršič, Massimiliano Di Filippo, Lorenzo Gaetani, Michaela Hassler, Cyra Leurs, Dejan Milosavljevic, Vincent van Pesch, Thor Petersen, Stefan Presslauer, Igal Rosenstein, Uroš Rot, Christine Schnabl, Charlotte Teunissen, Domizia Vecchio, Marco Vercellino, Florian Deisenhammer
Opublikowane w: Frontiers in Immunology, Numer 14, 2023, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1327947

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Autorzy: Antonella Fazio, Dora Bordoni, Jan W. P. Kuiper, Saskia Weber-Stiehl, Stephanie T. Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P. Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra & Philip Rosenstiel
Opublikowane w: Nature communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-33844-2

Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis

Autorzy: Zoë YGJ van Lierop, Samantha Noteboom, Martijn D Steenwijk, Maureen van Dam, Alyssa A Toorop, Zoé LE van Kempen, Bastiaan Moraal, Frederik Barkhof, Bernard MJ Uitdehaag, Menno M Schoonheim, Charlotte E Teunissen, Joep Killestein
Opublikowane w: Multiple Sclerosis Journal, Numer 28, 2025, Strona(/y) 2231-2242, ISSN 1352-4585
Wydawca: SAGE Publications
DOI: 10.1177/13524585221118676

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease

Autorzy: Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl
Opublikowane w: Gut Microbes, Numer 17, 2025, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2025.2452250

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma

Autorzy: Lars H. Nordenmark, Ph.D., Åsa Hellqvist, M.Sc., Claire Emson, Ph.D., Sarah Diver, M.D., Celeste Porsbjerg, M.D., Ph.D., Janet M. Griffiths, Ph.D., John D. Newell, Jr, M.D., +5, and Christopher E. Brightling, F.Med.Sci.
Opublikowane w: NEJM Evidence, 2023, ISSN 2766-5526
Wydawca: NEJM group
DOI: 10.1056/evidoa2300135

Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential

Autorzy: Ana Cvetko, Domagoj Kifer, Olga Gornik, Lucija Klarić, Elizabeth Visser, Gordan Lauc, James F. Wilson, Tamara Štambuk
Opublikowane w: Biomedicines, Numer 8/10, 2020, Strona(/y) 410, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines8100410

Autorzy: Morell M., Pérez-Cózar F, Marañón C.
Opublikowane w: International Journal of Molecular Science, Numer 14220067, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22137143

Stabilization of Human Whole Blood Samples for Multicenter and Retrospective Immunophenotyping Studies

Autorzy: Paulina Rybakowska, Catalina Burbano, Sofie Van Gassen, Nieves Varela, Rocío Aguilar‐Quesada, Yvan Saeys, Marta E. Alarcón‐Riquelme, Concepción Marañón
Opublikowane w: Cytometry Part A, 2020, ISSN 1552-4922
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24241

PeacoQC: Peak-based selection of high quality cytometry data

Autorzy: Annelies Emmaneel, Katrien Quintelier, Dorine Sichien, Paulina Rybakowska, Concepción Marañón, Marta E. Alarcón-Riquelme, Gert Van Isterdael, Sofie Van Gassen, Yvan Saeys
Opublikowane w: Cytometry Part A, Numer 15524930, 2021, Strona(/y) 325-338, ISSN 1552-4930
Wydawca: International Society for Advancement of Cytometry
DOI: 10.1002/cyto.a.24501

YOUPI: Your powerful and intelligent tool for segmenting cells from imaging mass cytometry data

Autorzy: Yvonne Scuiller, Patrice Hemon, Marion Le Rochais, Jacques-Olivier Pers, Christophe Jamin, Nathan Foulquier
Opublikowane w: Frontiers in Immunology, Numer 14, 2023, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1072118

Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis

Autorzy: Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, Lorenzo Beretta, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux,
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Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants

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Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole‐Blood Transcriptomics Data

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Pheno-Ranker: a toolkit for comparison of phenotypic data stored in GA4GH standards and beyond

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Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis

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9-HODE associates with thalamic atrophy and predicts white matter damage in multiple sclerosis

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Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis

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HLA-DRB1 and HLA-DQA1 associated with immunogenicity to adalimumab therapy in patients with rheumatoid arthritis

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Why Is Multiple Sclerosis More Frequent in Women? Role of the Immune System and of Oral and Gut Microbiota

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Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease

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Rare Variants in Systemic Lupus Erythematosus: From Monogenic to Polygenic Disease

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Scoring personalized molecular portraits identify Systemic Lupus Erythematosus subtypes and predict individualized drug responses, symptomatology and disease progression

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Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus

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Narrative review to capture patients’ perceptions and opinions about non-response and response to biological therapy for severe asthma

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Predictors of Response to Biologics for Severe Asthma: A Systematic Review and Meta‐Analysis

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The Potential of Computational Modeling to Predict Disease Course and Treatment Response in Patients with Relapsing Multiple Sclerosis

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Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A systematic review and meta-analysis

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Optimized network inference for immune diseased single cells

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Identifying and appraising outcome measures for severe asthma: a systematic review

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Patient Reported Outcomes in Chronic Inflammatory Diseases: Current State, Limitations and Perspectives

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Identification of urinary bacterial genes as biomarkers for non-invasive diagnosis of renal lupus

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Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples

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Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

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Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Autorzy: Florian Tran, Christine Klein, Alexander Arlt, Simon Imm, Evelyn Knappe, Alison Simmons, Philip Rosenstiel, Philip Seibler
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Tryptophan degradation as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases

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OP0231 MASS CYTOMETRY DATA RECLASSIFY SYSTEMIC AUTOIMMUNE DISEASE PATIENTS IN PHENOTYPICALLY DISTINCTIVE GROUPS

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3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD.

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Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus

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Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma

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Risankizumab in severe asthma: A Phase IIa, placebo-controlled study

Autorzy: Brightling, Christopher E.; Nair, Parameswaran; Louis, Renaud; Singh, Dave
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Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design

Autorzy: Smith SJ, Gillespie L, Heaney LG, Brightling CE , McConnachie A¬, Siddiqui S, Mistry V4, Brown V , Jackson DJ, Lee NW, Fowler SJ, Mansur AH, Burhan H, Saralaya D, Kurukulaaratchy R, Nasser S, Pfeffer P, Brown T, Lordan J, Pavord ID, Chaudhuri R.
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Wydawca: European Respiratory Society
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Outcome measures and predictors of response to biological treatments for severe asthma

Autorzy: Anna Rattu
Opublikowane w: 2024
Wydawca: n/a

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