The Xdrop™ technology provides new opportunities for genomic analysis. Long regions of ~ 100 kb can be captured and sequenced based on very limited genomic information. In this way, any genomic regions, including insertions, deletions, repeats, gaps, and any structural variation, can be investigated. This is especially valuable in the context of large genomes, genomes for which a reference is not available, or those regions in the human genome underlying the genetic cause of diseases. Basic research questions will be answered, but the technology has also already been used by our partners on clinical samples. Our experience from the project highlights the importance of investing time and effort in user interaction, deeply understanding their needs, and developing new features accordingly. Accordingly, the Xdrop™ technology has been optimized in the project to solve different applications such as CRISPR editing verification, amplification of the whole genome from single human cells, and high throughput screening of cells.
The Xdrop™ technology has the potential to solve many more questions. The ultra-high throughput screening capacity of up to 1 billion compartments per day, that can be achieved with the new Xdrop Sort, has made the technology relevant for a broader market including also high throughput screening of bacterial and mammalian cells. Thus, we will continue expanding the use and work towards “Improving DNA Analysis for Correct Healthcare”.
