RAtional design of canceR ImmunoTherapY: one size does not fit all

Rezultaty

The participant will submit a plan describing how to deal with the research data generated in the current project

Publikacje

Visual cohort comparison for spatial single-cell omics-data

Autorzy: Antonios Somarakis, Marieke E. Ijsselsteijn, Sietse J. Luk, Boyd Kenkhuis, Noel F.C.C. de Miranda, Boudewijn P.F. Lelieveldt, Thomas Hollt
Opublikowane w: IEEE Transactions on Visualization and Computer Graphics, Numer 27/2, 2021, Strona(/y) 733-743, ISSN 1077-2626
Wydawca: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tvcg.2020.3030336

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Autorzy: Marieke E. Ijsselsteijn, Antonios Somarakis, Boudewijn P. F. Lelieveldt, Thomas Höllt, Noel F. C. C. Miranda
Opublikowane w: Cytometry Part A, 2021, ISSN 1552-4922
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.24480

PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics

Autorzy: A.M. Sequeira, M.E. Ijsselsteijn, M. Rocha, Noel F.C.C. de Miranda
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 23, 2025, Strona(/y) 3920-3928, ISSN 2001-0370
Wydawca: Elsevier BV
DOI: 10.1016/j.csbj.2024.10.048

Cancer-Associated Fibroblasts Are Key Determinants of Cancer Cell Invasion in the Earliest Stage of Colorectal Cancer

Autorzy: Hao Dang, Tom J. Harryvan, Chen-Yi Liao, Erik H.J. Danen, Vienna N.L.N. Spalburg, Szymon M. Kielbasa, Hailiang Mei, Jelle J. Goeman, Eveline S. de Jonge-Muller, Stefanus G.T. Janson, Johan J. van der Reijden, Stijn Crobach, James C.H. Hardwick, Jurjen J. Boonstra, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Opublikowane w: Cellular and Molecular Gastroenterology and Hepatology, Numer 16, 2024, Strona(/y) 107-131, ISSN 2352-345X
Wydawca: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2023.04.004

Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling

Autorzy: Joana B. Nunes, Marieke E. Ijsselsteijn, Tamim Abdelaal, Rick Ursem, Manon van der Ploeg, Martin Giera, Bart Everts, Ahmed Mahfouz, Bram Heijs, Noel F. C. C. de Miranda
Opublikowane w: Nature Methods, Numer 21, 2024, Strona(/y) 1796-1800, ISSN 1548-7091
Wydawca: Nature Publishing Group
DOI: 10.1038/s41592-024-02392-6

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden

Autorzy: Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda
Opublikowane w: Journal for ImmunoTherapy of Cancer, Numer 11, 2024, Strona(/y) e005887, ISSN 2051-1426
Wydawca: SITC
DOI: 10.1136/jitc-2022-005887

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Autorzy: Jessica Roelands; Manon van der Ploeg; Marieke E Ijsselsteijn; Hao Dang; Jurjen J Boonstra; James C H Hardwick; Lukas J A C Hawinkels; Hans Morreau; Noel F C C de Miranda
Opublikowane w: Gut, Numer 1, 2022, ISSN 1468-3288
Wydawca: BMJ
DOI: 10.1136/gutjnl-2022-327608

Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry

Autorzy: Brouwer TP, de Vries NL, Abdelaal T, Krog RT, Li Z, Ruano D, Fariña A, Lelieveldt BPF, Morreau H, Bonsing BA, Vahrmeijer AL, Koning F, de Miranda NFCC
Opublikowane w: J Immunother Cancer, 2022, ISSN 2051-1426
Wydawca: BMJ
DOI: 10.1136/jitc-2022-004638

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies

Autorzy: Thomas Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies, Julia Walker, Robbert M. Spaapen, Hanna Kok, Demi Houg, Milena Viyacheva, Yvonne B. Claassen, Manuel Saornil, Oscar Krijgsman, Bas Stringer, Huiwen Ding, Anou Geleijnse, Anne C. Meinema, Bianca Weissbrich, Melissa Lancee, Carmen G. Engele, Marianna Sabatino, Pei-Ling Chen, Kenneth Y. Tsai, James J. Mulé, Vernon
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-55420-6

Neoantigen Targetability in Progressive Advanced Melanoma

Autorzy: Jitske van den Bulk, Els M.E. Verdegaal, Manon van der Ploeg, Marten Visser, Joana B. Nunes, Arnoud H. de Ru, Rayman T.N. Tjokrodirijo, Marieke E. Ijsselsteijn, Natasja I. Janssen, Ruud van der Breggen, Linda de Bruin, Pita de Kok, George M.C. Janssen, Dina Ruano, Ellen H.W. Kapiteijn, Peter A. van Veelen, Noel F.C.C. de Miranda, Sjoerd H. van der Burg
Opublikowane w: Clinical Cancer Research, Numer 29, 2023, Strona(/y) 4278-4288, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-23-1106

Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival

Autorzy: Ziena Abdulrahman; Saskia J Santegoets; Gregor Sturm; Pornpimol Charoentong; Marieke E Ijsselsteijn; Antonios Somarakis; Thomas Höllt; Francesca Finotello; Zlatko Trajanoski; Sylvia L van Egmond; Dana A M Mustafa; Marij J P Welters; Noel F C C de Miranda; Sjoerd H van der Burg
Opublikowane w: J Immunother Cancer, Numer 2, 2022, ISSN 1756-1833
Wydawca: BMJ
DOI: 10.1136/jitc-2021-004346

Autologous dendritic cells pulsed with allogeneic tumour cell lysate induce tumour-reactive T-cell responses in patients with pancreatic cancer: A phase I study

Autorzy: S.P. Lau, L. Klaase, M. Vink, J. Dumas, K. Bezemer, A. van Krimpen, R. van der Breggen, L.V. Wismans, M. Doukas, W. de Koning, A.P. Stubbs, D.A.M. Mustafa, H. Vroman, R. Stadhouders, J.B. Nunes, C. Stingl, N.F.C.C. de Miranda, T.M. Luider, S.H. van der Burg, J.G. Aerts, C.H.J. van Eijck
Opublikowane w: European Journal of Cancer, Numer 169, 2022, Strona(/y) 20-31, ISSN 0959-8049
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2022.03.015

Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel

Autorzy: Thomas P. Brouwer, Alexander L. Vahrmeijer, Noel F. C. C. de Miranda
Opublikowane w: Cellular Oncology, Numer 44/2, 2021, Strona(/y) 261-278, ISSN 2211-3428
Wydawca: Springer Verlag
DOI: 10.1007/s13402-021-00587-z

Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Autorzy: Subinuer Abudukelimu, Noel F.C.C. de Miranda, Lukas J.A.C. Hawinkels
Opublikowane w: Cellular and Molecular Gastroenterology and Hepatology, Numer 17, 2024, Strona(/y) 821-826, ISSN 2352-345X
Wydawca: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2024.01.013

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Autorzy: Mark A Glaire, Neil AJ Ryan, Marieke E Ijsselsteijn, Katarzyna Kedzierska, Sofia Obolenski, Reem Ali, Emma J Crosbie, Tjalling Bosse, Noel FCC de Miranda, David N Church
Opublikowane w: The Journal of Pathology, Numer 257, 2023, Strona(/y) 340-351, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5894

Linking Immunity with Genomics in Sarcomas: Is Genomic Complexity an Immunogenic Trigger?

Autorzy: Siddh van Oost, Debora M. Meijer, Marieke L. Kuijjer, Judith V. M. G. Bovée, and Noel F. C. C. de Miranda
Opublikowane w: Biomedicines, 2021, ISSN 2078-2489
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines9081048

A Paradoxical Role for Regulatory T Cells in the Tumor Microenvironment of Pancreatic Cancer

Autorzy: Thomas Brouwer, Marieke Ijsselsteijn, Jan Oosting, Dina Ruano, Manon van der Ploeg, Frederike Dijk, Bert Bonsing, Arantza Fariña, Hans Morreau, Alexander Vahrmeijer, Noel de Miranda
Opublikowane w: Cancers, Numer 14, 2025, Strona(/y) 3862, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14163862

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Autorzy: Natasja L. de Vries, Joris van de Haar, Vivien Veninga, Myriam Chalabi, Marieke E. Ijsselsteijn, Manon van der Ploeg, Jitske van den Bulk, Dina Ruano, Jose G. van den Berg, John B. Haanen, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Thomas W. Battaglia, Hans Gelderblom, Henk M. W. Verheul, Ton N. Schumacher, Lodewyk F. A. Wessels, Frits Koning, Noel F. C. C. de Miranda, Emile E. Voest
Opublikowane w: Nature, Numer 613, 2023, Strona(/y) 743-750, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-05593-1

Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies

Autorzy: Natasja L. de Vries, Ahmed Mahfouz, Frits Koning, Noel F. C. C. de Miranda
Opublikowane w: Frontiers in Oncology, Numer 10, 2020, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01254

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Autorzy: Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Opublikowane w: Clinical Science, Numer 135/1, 2021, Strona(/y) 35-52, ISSN 0143-5221
Wydawca: Portland Press, Ltd.
DOI: 10.1042/cs20201236

Advancing multiplexed imaging for enhanced tissue complexity analysis

Autorzy: Marieke E. Ijsselsteijn, Noel F. C. C. de Miranda
Opublikowane w: Nature Methods, Numer 20, 2023, Strona(/y) 1280-1281, ISSN 1548-7091
Wydawca: Nature Publishing Group
DOI: 10.1038/s41592-023-01935-7

Rezultaty

Publikacje

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