ENable LIGHT- and synthetic biology-driven volumetric bioprinting of functional human tissues

Informacje na temat projektu

ENLIGHT

Identyfikator umowy o grant: 964497

DOI

10.3030/964497

Projekt został zamknięty

Data podpisania przez KE 22 Stycznia 2021

Data rozpoczęcia 1 Maja 2021

Data zakończenia 30 Kwietnia 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 594 925,00

Wkład UE

€ 3 594 925,00

Koordynowany przez

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

ENLIGHT logo and website

The ENLIGHT logo and first version of the project website will be delivered at M2Task involved T62

Documents, reports (2)

Infographs describing the project and its impact

After the first year infographs of the project and its impact will be made public through the website The infographs will be updated on the website throughout the projectTask involved T62

Management handbook

A management handbook will be written including templates meeting schedules and a detailed planning of activities as well as decisionmaking processesTasks involved T71 and T72

Publikacje

Peer reviewed articles (37)

Smartphone-Flashlight-Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type-1 Diabetes

Autorzy: Mansouri, Maysam; Xue, Shuai; Hussherr, Marie-Didiée; Strittmatter, Tobias; Camenisch, Gieri; Fussenegger, Martin
Opublikowane w: Small, Numer 4, 2021, ISSN 1613-6829
Wydawca: Wiley
DOI: 10.1002/smll.202101939

3D<i>in vitro</i>modeling of the exocrine pancreatic unit using tomographic volumetric bioprinting

Autorzy: Viola Sgarminato, Jorge Madrid-Wolff, Antoine Boniface, Gianluca Ciardelli, Chiara Tonda-Turo, Christophe Moser
Opublikowane w: Biofabrication, 2024, ISSN 1758-5090
Wydawca: IOP Publishing Ltd
DOI: 10.1101/2023.01.23.525142

Light from Afield: Fast, High-Resolution, and Layer-Free Deep Vat 3D Printing

Autorzy: Chansoria, Parth; id_orcid0000-0002-6107-6848; Rizzo, Riccardo; id_orcid0000-0001-8297-6776; Rütsche, Dominic; Liu, Hao; Delrot, Paul; Zenobi-Wong, Marcy; id_orcid0000-0002-8522-9909
Opublikowane w: Chemical Reviews, 124 (14), Numer 1, 2024, ISSN 0009-2665
Wydawca: American Chemical Society

Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies

Autorzy: Manon C. Bouwmeester, Paulina N. Bernal, Loes A. Oosterhoff, Monique E. van Wolferen, Vivian Lehmann, Monique Vermaas, Maj‐Britt Buchholz, Quentin C. Peiffer, Jos Malda, Luc J. W. van der Laan, Nynke I. Kramer, Kerstin Schneeberger, Riccardo Levato, Bart Spee
Opublikowane w: Macromolecular Bioscience, Numer 21, 2023, ISSN 1616-5187
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202100327

Liver Organoids: Updates on Disease Modeling and Biomedical Applications

Autorzy: Carmen Caiazza, Silvia Parisi, Massimiliano Caiazzo
Opublikowane w: Biology, Numer 10, 2024, Strona(/y) 835, ISSN 2079-7737
Wydawca: MDPI AG
DOI: 10.3390/biology10090835

Liver Organoids: Updates on Disease Modeling and Biomedical Applications.

Autorzy: Caiazza, Carmen; Parisi, Silvia; Caiazzo, Massimiliano; Afd Pharmaceutics; Pharmaceutics
Opublikowane w: Biology, Numer 1, 2021, ISSN 2079-7737
Wydawca: MDPI
DOI: 10.3390/biology10090835

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Autorzy: Paulina; Manon; Jorge; Marc; Sammy; Nuria; Gabriel; Roos-Anne; Monique; Luc; Paul; Damien; Jos; Christophe; Bart; Riccardo
Opublikowane w: Advanced Materials, Numer 1, 2022, ISSN 1521-4095
Wydawca: Wiley-VCH
DOI: 10.5281/zenodo.6380100

Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models

Autorzy: Boning Qiu, Sara Pompe, Katerina T. Xenaki, Alessia Di Maggio, Clara Belinchón Moreno, Paul M.P. van Bergen en Henegouwen, Enrico Mastrobattista, Sabrina Oliveira, Massimiliano Caiazzo
Opublikowane w: Journal of Controlled Release, Numer 383, 2025, Strona(/y) 113852, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113852

Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins

Autorzy: Mohamed Mahameed, Shuai Xue, Benjamin Danuser, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
Opublikowane w: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41551-025-01350-7

Glucose‐Operated Widget (GLOW) for Closed‐Loop Optogenetic Glycemic Control

Autorzy: Debasis Maity, Preetam Guha Ray, Martin Fussenegger
Opublikowane w: Advanced Materials, Numer 36, 2024, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202408537

Light-based vat-polymerization bioprinting

Autorzy: Riccardo Levato, Oksana Dudaryeva, Carlos Ezio Garciamendez-Mijares, Bruce E. Kirkpatrick, Riccardo Rizzo, Jacob Schimelman, Kristi S. Anseth, Shaochen Chen, Marcy Zenobi-Wong, Yu Shrike Zhang
Opublikowane w: Nature Reviews Methods Primers, Numer 3, 2024, ISSN 2662-8449
Wydawca: Nature
DOI: 10.1038/s43586-023-00231-0

Light-based vat-polymerization bioprinting

Autorzy: Riccardo Levato; Oksana Dudaryeva; Carlos Ezio Garciamendez-Mijares; Bruce E. Kirkpatrick; Riccardo Rizzo; Jacob Schimelman; Kristi S. Anseth; Shaochen Chen; Marcy Zenobi-Wong; Yu Shrike Zhang
Opublikowane w: Nature Reviews Methods Primers, 3, Numer 1, 2023, ISSN 2662-8449
Wydawca: Nature
DOI: 10.1038/s43586-023-00231-0

Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels

Autorzy: Davide Ribezzi, Marième Gueye, Sammy Florczak, Franziska Dusi, Dieuwke de Vos, Francesca Manente, Andreas Hierholzer, Martin Fussenegger, Massimiliano Caiazzo, Torsten Blunk, Jos Malda, Riccardo Levato
Opublikowane w: Advanced Materials, 2023, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202301673

Engineering electrogenetic interfaces for mammalian cell control

Autorzy: Maysam Mansouri, Martin Fussenegger
Opublikowane w: Cell Chemical Biology, Numer 32, 2025, Strona(/y) 521-528, ISSN 2451-9456
Wydawca: Elsevier BV
DOI: 10.1016/j.chembiol.2025.01.003

A review of materials used in tomographic volumetric additive manufacturing

Autorzy: Jorge Madrid-Wolff, Joseph Toombs, Riccardo Rizzo, Paulina Nuñez Bernal, Dominique Porcincula, Rebecca Walton, Bin Wang, Frederik Kotz-Helmer, Yi Yang, David Kaplan, Yu Shrike Zhang, Marcy Zenobi-Wong, Robert R. McLeod, Bastian Rapp, Johanna Schwartz, Maxim Shusteff, Hayden Talyor, Riccardo Levato, Christophe Moser
Opublikowane w: MRS Communications, Numer 13, 2023, Strona(/y) 764-785, ISSN 2159-6867
Wydawca: Springer Science and Business Media LLC
DOI: 10.1557/s43579-023-00447-x

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

Autorzy: Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23572-4

Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuli

Autorzy: Silvia Galvan, Ana P. Teixeira, Martin Fussenegger
Opublikowane w: Biotechnology and Bioengineering, Numer 121, 2025, Strona(/y) 2987-3000, ISSN 0006-3592
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28770

Bioprinting and synthetic biology approaches to engineer functional endocrine pancreatic constructs

Autorzy: Davide Ribezzi, Pere Català, Cataldo Pignatelli, Antonio Citro, Riccardo Levato
Opublikowane w: Trends in Biotechnology, 2025, ISSN 0167-7799
Wydawca: Elsevier BV
DOI: 10.1016/j.tibtech.2025.03.005

Delivery Systems in Neuronal Direct Cell Reprogramming

Autorzy: Giulia Redi, Filomena Del Piano, Sara Cappellini, Martina Paladino, Anne den Breejen, Marcel H.A.M. Fens, Massimiliano Caiazzo
Opublikowane w: Cellular Reprogramming, 2025, ISSN 2152-4971
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/cell.2025.0008

Brain Organoids: Filling the Need for a Human Model of Neurological Disorder

Autorzy: Philip Jalink, Massimiliano Caiazzo
Opublikowane w: Biology, Numer 10, 2025, Strona(/y) 740, ISSN 2079-7737
Wydawca: MDPI
DOI: 10.3390/biology10080740

A review of materials used in tomographic volumetric additive manufacturing

Autorzy: Jorge Madrid-Wolff; Joseph Toombs; Riccardo Rizzo; Paulina Nuñez Bernal; Dominique Porcincula; Rebecca Walton; Bin Wang; Frederik Kotz-Helmer; Yi Yang; David Kaplan; Yu Shrike Zhang; Marcy Zenobi-Wong; Robert R. McLeod; Bastian Rapp; Johanna Schwartz; Maxim Shusteff; Hayden Talyor; Riccardo Levato; Christophe Moser
Opublikowane w: MRS Communications, Numer 3, 2023, ISSN 2159-6867
Wydawca: Springer Link
DOI: 10.1557/s43579-023-00447-x

MicroRNA Roles in Cell Reprogramming Mechanisms

Autorzy: Pascale, Emilia; Caiazza, Carmen; Paladino, Martina; Parisi, Silvia; Passaro, Fabiana; Caiazzo, Massimiliano
Opublikowane w: Cells, Numer 3, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11060940

Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges

Autorzy: Tommaso Zandrini, Sammy Florczak, Riccardo Levato, and Aleksandr Ovsianikov
Opublikowane w: Trends in Biotechnology, 2022, ISSN 0167-7799
Wydawca: Elsevier BV
DOI: 10.1016/j.tibtech.2022.10.009

Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures

Autorzy: Simona Aversano, Carmen Caiazza, Massimiliano Caiazzo
Opublikowane w: Frontiers in Aging Neuroscience, 2022, ISSN 1663-4365
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.1069482

Levodopa-loaded nanoparticles for the treatment of Parkinson's disease

Autorzy: Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H.A.M. Fens
Opublikowane w: Journal of Controlled Release, Numer 360, 2023, Strona(/y) 212-224, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2023.06.026

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactor

Autorzy: Paulina Nuñez Bernal,Manon Bouwmeester,Jorge Madrid-Wolff,Marc Falandt,Sammy Florczak,Nuria Ginés Rodriguez,Yang Li,Gabriel Größbacher,Roos-Anne Samsom,Monique van Wolferen,Luc J. W. van der Laan,Paul Delrot,Damien Loterie,Jos Malda,Christophe Moser,Bart Spee,Riccardo Levato
Opublikowane w: Advanced Materials, 2022, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202110054

Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs

Autorzy: Bram G. Soliman, Alessia Longoni, Mian Wang, Wanlu Li, Paulina N. Bernal, Alessandro Cianciosi, Gabriella C.J. Lindberg, Jos Malda, Juergen Groll, Tomasz Jungst, Riccardo Levato, Jelena Rnjak-Kovacina, Tim B. F. Woodfield, Yu Shrike Zhang, Khoon S. Lim
Opublikowane w: Advanced Functional Materials, 2023, ISSN 1616-301X
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202210521

Design of programmable post-translational switch control platform for on-demand protein secretion in mammalian cells

Autorzy: Maysam Mansouri, Preetam Guha Ray, Nik Franko, Shuai Xue, Martin Fussenegger
Opublikowane w: Nucleic Acids Research, 2023, ISSN 1362-4962
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkac916

Controlling Light in Scattering Materials for Volumetric Additive Manufacturing

Autorzy: Madrid-Wolff, Jorge; Boniface, Antoine; Loterie, Damien; Delrot, Paul; Moser, Christophe
Opublikowane w: Advanced Science, Numer 1, 2022, ISSN 2198-3844
Wydawca: Wiley
DOI: 10.1002/advs.202105144

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

Autorzy: Maysam Mansouri, Martin Fussenegger
Opublikowane w: Protein &amp; Cell, Numer 13, 2023, Strona(/y) 476-489, ISSN 1674-8018
Wydawca: Oxford University Press (OUP)
DOI: 10.1007/s13238-021-00876-1

Small‐Molecule Regulators for Gene Switches to Program Mammalian Cell Behaviour

Autorzy: Maysam Mansouri, Martin Fussenegger
Opublikowane w: ChemBioChem, Numer 25, 2025, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202300717

Light from Afield: Fast, High-Resolution, and Layer-Free Deep Vat 3D Printing

Autorzy: Parth Chansoria, Riccardo Rizzo, Dominic Rütsche, Hao Liu, Paul Delrot, Marcy Zenobi-Wong
Opublikowane w: Chemical Reviews, Numer 124, 2024, Strona(/y) 8787-8822, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.4c00134

Engineering receptors in the secretory pathway for orthogonal signalling control

Autorzy: Mohamed Mahameed, Pengli Wang, Shuai Xue & Martin Fussenegger
Opublikowane w: Nature Communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-35161-0

Volumetric Printing Across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

Autorzy: Gabriel Größbacher, Michael Bartolf-Kopp, Csaba Gergely, Paulina Núñez Bernal, Sammy Florczak, Mylène de Ruijter, Núria Ginés Rodriguez, Jürgen Groll, Jos Malda, Tomasz Jungst, Riccardo Levato
Opublikowane w: Advanced Materials, 2023, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300756

Inverse Rendering for Tomographic Volumetric Additive Manufacturing

Autorzy: Baptiste Nicolet, Felix Wechsler, Jorge Madrid-Wolff, Christophe Moser, Wenzel Jakob
Opublikowane w: ACM Transactions on Graphics, Numer 43, 2024, Strona(/y) 1-17, ISSN 0730-0301
Wydawca: Association for Computing Machinary, Inc.
DOI: 10.1145/3687924

The road ahead in materials and technologies for volumetric 3D printing

Autorzy: Paulina Nunez Bernal, Sammy Florczak, Sebastian Inacker, Xiao Kuang, Jorge Madrid-Wolff, Martin Regehly, Stefan Hecht, Yu Shrike Zhang, Christophe Moser, Riccardo Levato
Opublikowane w: Nature Reviews Materials, 2025, ISSN 2058-8437
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41578-025-00785-3

Biofabricating the vascular tree in engineered bone tissue

Autorzy: Leanne de Silva, Paulina N. Bernal, AJW Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Opublikowane w: Acta Biomaterialia, 2023, Strona(/y) 250-268, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2022.08.051

Other (1)

Exploring RRI in Bioprinted Organoids: Reflections from the ENLIGHT project

Autorzy: Simone, Angela; Pellizzone, Anna
Opublikowane w: Numer 1, 2025
Wydawca: Zenodo
DOI: 10.5281/zenodo.15372410

Book chapters (1)

Posttranslational Remote Control Mediated by Physical Inducers for Rapid Protein Release in Engineered Mammalian Cells

Autorzy: Maysam Mansouri, Martin Fussenegger
Opublikowane w: Methods in Molecular Biology, Mammalian Synthetic Systems, 2024, Strona(/y) 233-241, ISBN 978-1-0716-3718-0
Wydawca: Springer US
DOI: 10.1007/978-1-0716-3718-0_15

Non-peer reviewed articles (1)

Multi‐material Volumetric Bioprinting and Plug‐and‐play Suspension Bath Biofabrication via Bioresin Molecular Weight Tuning and via Multiwavelength Alignment Optics

Autorzy: Davide Ribezzi, Jan‐Philip Zegwaart, Thomas Van Gansbeke, Aitor Tejo‐Otero, Sammy Florczak, Joska Aerts, Paul Delrot, Andreas Hierholzer, Martin Fussenegger, Jos Malda, Jos Olijve, Riccardo Levato
Opublikowane w: Advanced Materials, Numer 37, 2025, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202409355